The movie follows Andy, a brilliant chemist and inventor (played by Seth Rogen) who is embarking on a cross-country road trip to find distributors for his new organic-cleaning fluid. But first, he stops to say good-bye to his mother who ends up tagging along which is when hilarity (and endless nagging) ensues.
The only "real" destination in the film (outside of a few on location shoots that took place within the 45 minute zone around Barbra's mansion) is Las Vegas. Last year the cast and crew spent a few days filming in Caesars Palace, where Barbra cheated at card games in her spare time.
If you want to see America on a green screen, The Guilt Trip opens nationwide today.